diff --git a/packages/react-native-web/src/exports/AppRegistry/__tests__/__snapshots__/index-test.js.snap b/packages/react-native-web/src/exports/AppRegistry/__tests__/__snapshots__/index-test.js.snap
index c5d22bea8..597eebcf9 100644
--- a/packages/react-native-web/src/exports/AppRegistry/__tests__/__snapshots__/index-test.js.snap
+++ b/packages/react-native-web/src/exports/AppRegistry/__tests__/__snapshots__/index-test.js.snap
@@ -16,11 +16,11 @@ exports[`AppRegistry runApplication styles roots in different documents 1`] = `
   ".r-bottom-1p0dtai {bottom: 0px;}",
   ".r-left-1d2f490 {left: 0px;}",
   ".r-pointerEvents-105ug2t {pointer-events: auto !important;}",
-  ".r-pointerEvents-12vffkv * {pointer-events: auto;}",
+  ".r-pointerEvents-12vffkv>* {pointer-events: auto;}",
   ".r-pointerEvents-12vffkv {pointer-events: none !important;}",
-  ".r-pointerEvents-633pao * {pointer-events: none;}",
+  ".r-pointerEvents-633pao>* {pointer-events: none;}",
   ".r-pointerEvents-633pao {pointer-events: none !important;}",
-  ".r-pointerEvents-ah5dr5 * {pointer-events: none;}",
+  ".r-pointerEvents-ah5dr5>* {pointer-events: none;}",
   ".r-pointerEvents-ah5dr5 {pointer-events: auto !important;}",
   ".r-position-u8s1d {position: absolute;}",
   ".r-right-zchlnj {right: 0px;}",
@@ -44,11 +44,11 @@ exports[`AppRegistry runApplication styles roots in different documents 2`] = `
   ".r-bottom-1p0dtai {bottom: 0px;}",
   ".r-left-1d2f490 {left: 0px;}",
   ".r-pointerEvents-105ug2t {pointer-events: auto !important;}",
-  ".r-pointerEvents-12vffkv * {pointer-events: auto;}",
+  ".r-pointerEvents-12vffkv>* {pointer-events: auto;}",
   ".r-pointerEvents-12vffkv {pointer-events: none !important;}",
-  ".r-pointerEvents-633pao * {pointer-events: none;}",
+  ".r-pointerEvents-633pao>* {pointer-events: none;}",
   ".r-pointerEvents-633pao {pointer-events: none !important;}",
-  ".r-pointerEvents-ah5dr5 * {pointer-events: none;}",
+  ".r-pointerEvents-ah5dr5>* {pointer-events: none;}",
   ".r-pointerEvents-ah5dr5 {pointer-events: auto !important;}",
   ".r-position-u8s1d {position: absolute;}",
   ".r-right-zchlnj {right: 0px;}",
diff --git a/packages/react-native-web/src/exports/AppRegistry/__tests__/index-test.node.js b/packages/react-native-web/src/exports/AppRegistry/__tests__/index-test.node.js
index 821b73b1d..082bdd1fe 100644
--- a/packages/react-native-web/src/exports/AppRegistry/__tests__/index-test.node.js
+++ b/packages/react-native-web/src/exports/AppRegistry/__tests__/index-test.node.js
@@ -61,11 +61,11 @@ describe('AppRegistry', () => {
         .r-left-1d2f490{left:0px;}
         .r-maxWidth-dnmrzs{max-width:100%;}
         .r-pointerEvents-105ug2t{pointer-events:auto!important;}
-        .r-pointerEvents-12vffkv * {pointer-events:auto;}
+        .r-pointerEvents-12vffkv>* {pointer-events:auto;}
         .r-pointerEvents-12vffkv{pointer-events:none!important;}
-        .r-pointerEvents-633pao * {pointer-events:none;}
+        .r-pointerEvents-633pao>* {pointer-events:none;}
         .r-pointerEvents-633pao{pointer-events:none!important;}
-        .r-pointerEvents-ah5dr5 * {pointer-events:none;}
+        .r-pointerEvents-ah5dr5>* {pointer-events:none;}
         .r-pointerEvents-ah5dr5{pointer-events:auto!important;}
         .r-position-u8s1d{position:absolute;}
         .r-right-zchlnj{right:0px;}
@@ -120,11 +120,11 @@ describe('AppRegistry', () => {
         .r-left-1d2f490{left:0px;}
         .r-maxWidth-dnmrzs{max-width:100%;}
         .r-pointerEvents-105ug2t{pointer-events:auto!important;}
-        .r-pointerEvents-12vffkv * {pointer-events:auto;}
+        .r-pointerEvents-12vffkv>* {pointer-events:auto;}
         .r-pointerEvents-12vffkv{pointer-events:none!important;}
-        .r-pointerEvents-633pao * {pointer-events:none;}
+        .r-pointerEvents-633pao>* {pointer-events:none;}
         .r-pointerEvents-633pao{pointer-events:none!important;}
-        .r-pointerEvents-ah5dr5 * {pointer-events:none;}
+        .r-pointerEvents-ah5dr5>* {pointer-events:none;}
         .r-pointerEvents-ah5dr5{pointer-events:auto!important;}
         .r-position-u8s1d{position:absolute;}
         .r-right-zchlnj{right:0px;}
@@ -172,11 +172,11 @@ describe('AppRegistry', () => {
         .r-left-1d2f490{left:0px;}
         .r-maxWidth-dnmrzs{max-width:100%;}
         .r-pointerEvents-105ug2t{pointer-events:auto!important;}
-        .r-pointerEvents-12vffkv * {pointer-events:auto;}
+        .r-pointerEvents-12vffkv>* {pointer-events:auto;}
         .r-pointerEvents-12vffkv{pointer-events:none!important;}
-        .r-pointerEvents-633pao * {pointer-events:none;}
+        .r-pointerEvents-633pao>* {pointer-events:none;}
         .r-pointerEvents-633pao{pointer-events:none!important;}
-        .r-pointerEvents-ah5dr5 * {pointer-events:none;}
+        .r-pointerEvents-ah5dr5>* {pointer-events:none;}
         .r-pointerEvents-ah5dr5{pointer-events:auto!important;}
         .r-position-u8s1d{position:absolute;}
         .r-right-zchlnj{right:0px;}
diff --git a/packages/react-native-web/src/exports/StyleSheet/__tests__/compiler-test.js b/packages/react-native-web/src/exports/StyleSheet/__tests__/compiler-test.js
index 6709f69e1..e47121b1b 100644
--- a/packages/react-native-web/src/exports/StyleSheet/__tests__/compiler-test.js
+++ b/packages/react-native-web/src/exports/StyleSheet/__tests__/compiler-test.js
@@ -142,7 +142,7 @@ describe('StyleSheet/compile', () => {
             ],
             [
               [
-                ".r-pointerEvents-ah5dr5 * {pointer-events:none;}",
+                ".r-pointerEvents-ah5dr5>* {pointer-events:none;}",
                 ".r-pointerEvents-ah5dr5{pointer-events:auto!important;}",
               ],
               3,
@@ -191,7 +191,7 @@ describe('StyleSheet/compile', () => {
           [
             [
               [
-                ".r-pointerEvents-633pao * {pointer-events:none;}",
+                ".r-pointerEvents-633pao>* {pointer-events:none;}",
                 ".r-pointerEvents-633pao{pointer-events:none!important;}",
               ],
               3,
@@ -215,7 +215,7 @@ describe('StyleSheet/compile', () => {
           [
             [
               [
-                ".r-pointerEvents-12vffkv * {pointer-events:auto;}",
+                ".r-pointerEvents-12vffkv>* {pointer-events:auto;}",
                 ".r-pointerEvents-12vffkv{pointer-events:none!important;}",
               ],
               3,
diff --git a/packages/react-native-web/src/exports/StyleSheet/compiler/index.js b/packages/react-native-web/src/exports/StyleSheet/compiler/index.js
index 7649d9888..61f9f5c35 100644
--- a/packages/react-native-web/src/exports/StyleSheet/compiler/index.js
+++ b/packages/react-native-web/src/exports/StyleSheet/compiler/index.js
@@ -387,15 +387,15 @@ function createAtomicRules(identifier: string, property, value): Rules {
       } else if (value === 'none') {
         finalValue = 'none!important';
         const block = createDeclarationBlock({ pointerEvents: 'none' });
-        rules.push(`${selector} * ${block}`);
+        rules.push(`${selector}>* ${block}`);
       } else if (value === 'box-none') {
         finalValue = 'none!important';
         const block = createDeclarationBlock({ pointerEvents: 'auto' });
-        rules.push(`${selector} * ${block}`);
+        rules.push(`${selector}>* ${block}`);
       } else if (value === 'box-only') {
         finalValue = 'auto!important';
         const block = createDeclarationBlock({ pointerEvents: 'none' });
-        rules.push(`${selector} * ${block}`);
+        rules.push(`${selector}>* ${block}`);
       }
       const block = createDeclarationBlock({ pointerEvents: finalValue });
       rules.push(`${selector}${block}`);