I have seen all this in:
Android: 16.
Retroarch : 1.22.2.
Genesis-Plus-GX: 1.7.4 c858c9c.
In the scene cuts, the geometry of the image appears to be deformed by a frame. (This effect is noticeable as soon as the SEGA logo disappears with Sonic next to it) After this in the start menus the spearheads that indicate the selection flash irregularly and respond to the controls inputs also irregularly. After this, when you start the game, only a black screen remains.
none of these behaviors are seen in the Genesis-Plus-GX-Wide core or another kernel for Sega CD emulation.
PS- although on the Genesis-Plus-GX-Wide core the Load times between scene cuts seem somewhat long.