diff --git a/config/jobs/etcd/etcd-periodics.yaml b/config/jobs/etcd/etcd-periodics.yaml
index 9018f2516e08..4f943dcb9a57 100644
--- a/config/jobs/etcd/etcd-periodics.yaml
+++ b/config/jobs/etcd/etcd-periodics.yaml
@@ -35,6 +35,40 @@ periodics:
     nodeSelector:
       kubernetes.io/arch: arm64
 
+- name: ci-etcd-e2e-ppc64le
+  interval: 4h
+  cluster: k8s-infra-ppc64le-prow-build
+  decorate: true
+  decoration_config:
+    timeout: 60m
+  extra_refs:
+    - org: etcd-io
+      repo: etcd
+      base_ref: main
+  annotations:
+    testgrid-dashboards: sig-etcd-periodics, sig-etcd-ppc64le
+    testgrid-tab-name: ci-etcd-e2e-ppc64le
+  spec:
+    containers:
+      - image: us-central1-docker.pkg.dev/k8s-staging-test-infra/images/kubekins-e2e:v20250311-73aac21714-master
+        command:
+          - runner.sh
+        args:
+          - bash
+          - -c
+          - |
+            set -euo pipefail
+            VERBOSE=1 GOOS=linux GOARCH=ppc64le CPU=4 EXPECT_DEBUG=true make test-e2e-release
+        resources:
+          requests:
+            cpu: "4"
+            memory: "8Gi"
+          limits:
+            cpu: "4"
+            memory: "8Gi"
+    nodeSelector:
+      kubernetes.io/arch: ppc64le
+
 - name: ci-etcd-e2e-amd64
   interval: 4h
   cluster: eks-prow-build-cluster
diff --git a/config/testgrids/kubernetes/sig-etcd/config.yaml b/config/testgrids/kubernetes/sig-etcd/config.yaml
index f03edeb5b41c..c51eaca59417 100644
--- a/config/testgrids/kubernetes/sig-etcd/config.yaml
+++ b/config/testgrids/kubernetes/sig-etcd/config.yaml
@@ -3,6 +3,7 @@ dashboard_groups:
   dashboard_names:
   - sig-etcd-amd64
   - sig-etcd-arm64
+  - sig-etcd-ppc64le
   - sig-etcd-presubmits
   - sig-etcd-periodics
   - sig-etcd-postsubmits
@@ -17,6 +18,7 @@ dashboard_groups:
 dashboards:
   - name: sig-etcd-amd64
   - name: sig-etcd-arm64
+  - name: sig-etcd-ppc64le
   - name: sig-etcd-presubmits
   - name: sig-etcd-periodics
   - name: sig-etcd-postsubmits
diff --git a/config/tests/jobs/jobs_test.go b/config/tests/jobs/jobs_test.go
index 21bc60b2ee72..895375409aaf 100644
--- a/config/tests/jobs/jobs_test.go
+++ b/config/tests/jobs/jobs_test.go
@@ -1130,7 +1130,7 @@ func TestClusterName(t *testing.T) {
 	jobs := allStaticJobs()
 	for _, job := range jobs {
 		// Useful for identifiying how many jobs are running a specific cluster by omitting from this list
-		validClusters := []string{"default", "test-infra-trusted", "k8s-infra-aks-admin", "k8s-infra-kops-prow-build", "k8s-infra-prow-build", "k8s-infra-prow-build-trusted", "eks-prow-build-cluster"}
+		validClusters := []string{"default", "test-infra-trusted", "k8s-infra-aks-admin", "k8s-infra-kops-prow-build", "k8s-infra-prow-build", "k8s-infra-prow-build-trusted", "eks-prow-build-cluster", "k8s-infra-ppc64le-prow-build"}
 		if !slices.Contains(validClusters, job.Cluster) || job.Cluster == "" {
 			err := fmt.Errorf("must run in one of these clusters: %v, found: %v", validClusters, job.Cluster)
 			t.Errorf("%v: %v", job.Name, err)