When you connect X64DBG to IDA Pro and then a breakpoint hits within x64dbg, IDA Pro will (as expected) refresh and show that, but the problem is that when you want to step through within x64dbg, every single step will actually put the focus on IDA Pro again because it is reflecting the changes.
So that means that you have to always Alt + Tab just to get back into x64dbg after you stepped over a single instruction.
The idea is that ret-sync will refresh IDA Pro but it won't change the focus of the applications and let the user decide when to switch between the both.